Proteus is very user friendly software for simulation and PCB designing as well. Consider following points
In ISIS while placing a component, make sure your components have PCB packages (Shown in PCB preview), otherwise you have to add it manually.
After building you circuit in ISIS, to to Tools Netlist to ARES
In ARES, first draw the border of PCB.
Place the components manually or you can use ‘Auto placer’, Tools Auto Placer
Now wire all the components manually, by following connection guiding lines or you can use ‘Auto router’, Tools Auto router
After placement and routing, you PCB is ready, now you can visualize you PCB using 3D visualizer, which is really a great feature of proteus.
You can export your design in PDF to take printout for actual PCB manufacturing from Output Export graphics Export PDF file
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